Giants vs Patriots MNF 2025: Week 13 Odds, Expert Picks, Predictions, and Injury Report

Giants vs Patriots MNF 2025: Week 13 Odds, Expert Picks, Predictions, and Injury Report

The Week 13 Monday Night Football matchup features the New England Patriots hosting the New York Giants at Gillette Stadium. The Patriots are currently riding a nine-game winning streak, aiming to solidify their lead atop the AFC East, while the Giants are struggling through a six-game losing skid that recently led to the firing of their defensive coordinator Shane Bowen. Early betting odds have the Patriots favored by 7.5 points at home, with an over/under total set at 46.5 points.

Team Form and Coaching Impact

The Patriots, led by Coach Mike Vrabel, are enjoying a highly successful season in his first year in Foxborough, making him the favorite for Coach of the Year. New England’s hot streak includes a recent tough but victorious game against Cincinnati, despite several key injuries along their offensive line and defense. Conversely, the Giants have been faltering late in games frequently, especially in fourth quarters where they allow the most points in the league, resulting in close losses and a poor overall record. Following these collapses, their defensive coordinator was dismissed, which could trigger a temporary uplift in performance for New York on Monday night.

Giants vs Patriots Early Spread and Total Picks

The sportsbooks opened with the Giants as +7.5 underdogs, with the Patriots favored by more than a touchdown due to the stark contrast in recent performances. Some sharp money on the Patriots could push this line higher to -8 or -8.5. The Giants’ defensive struggles could be mitigated somewhat by their capable pass rush tactics, which might pressure Patriots quarterback Drake Maye, especially given Maye’s offensive line is missing a couple of starters. The Patriots are expected to lean on their strong running game and keep the ball moving to control the clock, which could limit scoring despite both quarterbacks’ downfield passing skills.

The early total pick favors the under 46.5 points. Despite quarterbacks known for deep throws, the Patriots are likely to use a run-heavy approach against a poor Giants run defense, while the weather forecast suggests wintery conditions with rain, snow, and cold winds that could hamper offensive explosions. A conservative game plan and challenging weather could suppress scoring on both sides.

Key Injury and Matchup Notes

New England has dealt with injuries to key offensive linemen, including rookie left tackle Will Campbell, impacting pass protection. The Giants’ pass rush will look to exploit these vulnerabilities to disrupt Maye. Offensively, Giants quarterback Jameis Winston's ability to launch the ball deep could challenge New England’s secondary, which often relies on man coverage. On defense, New York’s inability to stop the run and late-game lapses have been critical issues all season.

Viewing Information and Odds Summary

• Game: Giants vs Patriots, Week 13 NFL Monday Night Football

• Date/Time: Monday, December 1, 2025, 8:15 p.m. ET

• Location: Gillette Stadium, Foxborough, MA

• TV: ESPN

• Spread: Patriots -7.5

• Moneyline: Giants +313, Patriots -386

• Over/Under: 46.5 points

Predictions and Betting Insights

Experts lean towards the Patriots continuing their winning streak and covering the spread, but with the Giants being a competitive underdog capable of keeping the game close, the safer early betting recommendation is taking New York +7.5. The Patriots’ strong ground game combined with weather conditions might lead the total points to stay under 46.5. Bettors should monitor injury updates and weather forecasts closer to kickoff as they may influence line movement.

This matchup poses an intriguing contrast between a dominant, healthy Patriots squad and a Giants team desperate to avoid another close loss amid recent turmoil. While New England seems likely to win, the Giants have the personnel and motivation to cover the spread and make this a competitive Monday Night Football showdown.​