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NFL Injury Report – Week 16 (Fantasy Relevant)

NFL Injury Report – Week 16

Key Updates on Patrick Mahomes, Davante Adams, and More


Week 16 arrives with major injury implications across the league, including a franchise-altering development in Kansas City and several high-impact fantasy football situations. As fantasy managers navigate playoff matchups, staying current on injury status is critical.


Below is a full Week 16 NFL injury breakdown, featuring the latest updates, expected availability, and fantasy impact for the most relevant players.


Major Injury Updates


Patrick Mahomes – QB, Chiefs

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Status

Injury

Fantasy Impact

Out for season

Torn ACL

Significant downgrade to KC offense

Patrick Mahomes suffered a torn ACL in Week 15 against the Chargers, officially ending his season. The loss also eliminated Kansas City from playoff contention for the first time since 2014.


Gardner Minshew is expected to start the final two games against the Titans and Broncos, followed by a Week 18 matchup with the Raiders. While this is a clear downgrade, Minshew has previously shown the ability to keep fantasy-relevant weapons afloat. Expect reduced ceilings for Travis Kelce and Rashee Rice, though the Chiefs may use the final weeks to evaluate younger options like Brashard Smith and Jalen Royals.


Davante Adams – WR, Rams

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Status

Injury

Week 16 Outlook

Questionable

Hamstring

Likely out

Davante Adams exited Week 15 after pulling up on a route with a hamstring injury. Head coach Sean McVay stated postgame that the injury “didn’t look good,” though no firm timetable has been announced.


With the Rams already clinching a playoff spot, there is little incentive to rush Adams back. He is considered week-to-week and is unlikely to play Thursday night against Seattle. Fantasy managers should prepare alternatives.


Fantasy note: Tight end Colby Parkinson continues to emerge, scoring six touchdowns over his last six games and should be rostered in most formats.



Bam Knight – RB, Cardinals

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Status

Injury

Replacement

Doubtful

Ankle

Michael Carter

Knight was carted off the field after suffering a severe ankle sprain and is unlikely to play in Week 16. Michael Carter handled the bulk of the workload after Knight’s exit, totaling 94 yards on 18 touches.

Carter profiles as a priority waiver addition, while Emari Demercado is a deeper-league stash.



Devin Neal – RB, Saints

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Status

Injury

Backfield Outlook

Questionable

Hamstring

Thin RB room

The Saints’ injury issues at running back continue. With Alvin Kamara already sidelined, rookie Devin Neal exited early in Week 15. He still managed eight touches, 32 yards, and a touchdown before leaving.

If Neal misses time, New Orleans would rely on Audric Estime and Evan Hull unless Kamara returns. Upcoming matchups against the Jets and Titans remain favorable.



Bhayshul Tuten – RB, Jaguars

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Status

Injury

Fantasy Impact

Out

Finger surgery

Boost to Etienne

Tuten will miss multiple weeks following finger surgery. While his role was limited, his absence further solidifies Travis Etienne Jr. as a strong RB1/2 option, despite a challenging Week 16 matchup against Denver.


Wide Receiver Injury Watch


Luther Burden III – WR, Bears

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Status

Injury

Week 16 Note

Questionable

Ankle

Saturday game

Burden exited Week 15 but still posted six catches for 84 yards. He has been Chicago’s most reliable receiver with Rome Odunze sidelined. Head coach Ben Johnson stated Burden’s status for Saturday night against Green Bay remains uncertain.


Fantasy managers should monitor practice reports closely due to the Saturday kickoff.



Christian Watson – WR, Packers

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Status

Injury

Matchup Note

Questionable

Chest

High upside if active

Watson exited after a hard landing while covered by Pat Surtain II and did not return. Prior to Week 15, he had scored five touchdowns in four games and previously torched Chicago for a 4-89-2 line.

If active, he remains a volatile but high-upside play.


Week 16 NFL Injury Report


Quarterbacks

  • Patrick Mahomes, Chiefs (torn ACL) – Out for season

  • Tyrod Taylor, Jets (groin)

  • Jayden Daniels, Commanders (elbow) – Out for season


Running Backs

  • Alvin Kamara, Saints (knee)

  • Devin Neal, Saints (hamstring)

  • Woody Marks, Texans (ankle)

  • Chris Rodriguez Jr., Commanders (groin)

  • Nick Chubb, Texans (ribs)

  • Bam Knight, Cardinals (ankle)

  • Dylan Sampson, Browns (calf)

  • Bhayshul Tuten, Jaguars (finger) – Out


Wide Receivers

  • Drake London, Falcons (knee)

  • Davante Adams, Rams (hamstring)

  • Marvin Harrison Jr., Cardinals (heel)

  • Tee Higgins, Bengals (concussion)

  • Garrett Wilson, Jets (knee)

  • Rome Odunze, Bears (foot)

  • Quentin Johnston, Chargers (groin)

  • Pat Bryant, Broncos (hamstring)

  • Luther Burden III, Bears (ankle)

  • Christian Watson, Packers (chest)

  • Ricky Pearsall, 49ers (ankle and knee)


Tight Ends

  • Mason Taylor, Jets (neck)

  • Cade Otton, Buccaneers (knee)

  • David Njoku, Browns (knee)


Out for the Season

  • Tyreek Hill, Dolphins (knee)

  • Malik Nabers, Giants (knee)

  • Najee Harris, Chargers (Achilles)

  • Austin Ekeler, Commanders (Achilles)

  • James Conner, Cardinals (foot)

  • Antonio Gibson, Patriots (knee)

  • Miles Sanders, Cowboys (knee)

  • Brandon Aiyuk, 49ers (knee)

  • Kyler Murray, Cardinals (foot)

  • Daniel Jones, Colts (Achilles)

  • Patrick Mahomes, Chiefs (torn ACL)

  • Jayden Daniels, Commanders (elbow)


Players to Monitor Closely

  • Sam LaPorta, Lions (back) – slim chance to return

  • Garrett Wilson, Jets (knee)

  • Drake London, Falcons (knee)


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