Rams vs Buccaneers Prediction and Odds for Week 12 Sunday Night Football

The Tampa Bay Buccaneers will take a cross-country trip to face the Los Angeles Rams in a pivotal Week 12 matchup on Sunday, November 23, 2025. This prime-time NBC Sunday Night Football contest kicks off at 8:20 p.m. ET from SoFi Stadium in Los Angeles, reigniting a recent rivalry as Tampa Bay seeks to defend its slender NFC South lead against the surging Rams.​

Game Setting and Current Form

The Buccaneers enter Week 12 with a 6-4 record after consecutive losses to elite AFC opponents Cleveland and Buffalo, where Tampa Bay put up a strong fight but ultimately fell 44-32 in Buffalo. Their offensive output was impressive, generating over 360 total yards and six scoring drives, powered by a dominant running game (202 yards rushing) and three touchdowns from RB Sean Tucker. The defense showed flashes with three takeaways, but struggled to contain Josh Allen’s dynamic playmaking.​

Meanwhile, the Los Angeles Rams, sitting at 8-2, are on a hot streak with five straight wins that propelled them to the top of the NFC West. They locked down a critical 21-19 win over Seattle in Week 11, fueled by MVP-caliber quarterback Matthew Stafford, who boasts an outstanding 27-2 touchdown-to-interception ratio this season. Stafford’s efficient passing and the Rams’ opportunistic defense have established them as top contenders.​

Historical Rivalry and Recent Outcomes

The Buccaneers and Rams have met several times in recent seasons, including an intense NFC Divisional Round playoff clash in 2021. While Los Angeles holds a 3-2 edge in matchups against Tampa Bay under head coach Sean McVay, Tampa Bay won their last meeting in 2022 by a narrow 16-13 margin at home. Historically, the teams have faced off 29 times including playoffs, with the Rams leading the all-time series 19-10.​

WHO WILL WIN?

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  TAMPA BAY BUCCANEERS
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  LOS ANGELES RAMS

Key Matchup Dynamics

Tampa Bay’s offense, led by Baker Mayfield’s improving play and a versatile running attack featuring Sean Tucker, will need to maintain productivity against a Rams defense that has tightened up during their winning streak. Defensively, the Buccaneers must try to contain Stafford’s aerial attack and the Rams' multi-faceted offense, which consistently finds ways to score in red-zone opportunities.

Los Angeles’s success is built on balanced offense and opportunistic defense. Stafford’s leadership and connecting with key skill players have made the Rams a formidable team at home. Tampa Bay's defense ranks 7th in DVOA but has faced three of the four top passing offenses this season and struggled at times. This sets the stage for a high-stakes battle between Tampa Bay’s improving offense and the Rams’ potent passing game.​

Betting Lines and Predictions

As of the latest odds, the Rams are favored by 6.5 points, with a total point over/under set at 49.5. The moneyline sits around -298 for the Rams and +240 for the Buccaneers. Analysts predict a close contest but favor the Rams to extend their winning streak to six games. Predictions suggest a final score near Rams 28, Buccaneers 21, reflecting Tampa Bay’s resilient offense but Los Angeles’s overall edge.​

Fantasy Football Outlook

This Week 12 contest features intriguing fantasy football implications. The high projected scoring total signals potential for explosive performances. Matthew Stafford is anticipated to throw for around 260 yards, while Baker Mayfield may pass for approximately 240 yards. Running backs and receivers like Sean Tucker and Rams skill players could deliver productive fantasy outputs. The offensive action should offer plenty of opportunities for fantasy managers to find valuable starting options.​

Conclusion

Tampa Bay Buccaneers' cross-country trip to face the Los Angeles Rams is more than a regular-season game—it reignites a rivalry full of history and significance. Both teams bring contrasting strengths: the Bucs’ aggressive ground game and opportunistic defense against the Rams’ sharp passing attack and momentum. With the Buccaneers holding a slim lead in their division and the Rams atop theirs, Week 12 promises to be an electrifying prime-time showdown with playoff implications and fantasy relevance for NFL fans.​

The Buccaneers will need to execute on both sides of the ball and withstand the pressures of playing on the road against a confident Rams squad led by one of the NFL’s top quarterbacks. Expect a battle of wills, strategic adjustments, and plenty of exciting football action under the bright lights at SoFi Stadium.

This matchup is a must-watch for fans and bettors alike as Tampa Bay fights to protect its playoff aspirations while Los Angeles aims to continue its dominant run through the NFC West.

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