Philadelphia placed Will Shipley on injured reserve, and Saquon Barkley will miss a second straight game, leaving Dameon Pierce and Carson Steele as the healthy active-roster backs.

Buffalo broadened its offense, Drake Maye raised New England's ceiling, and four defenses changed the Week 6 outlook. Here is what is sustainable, what could break, and what fantasy managers should do.

Jalen Hurts, Lamar Jackson, Saquon Barkley, Baker Mayfield, Breece Hall and David Montgomery are out. Friday's verified Week 6 fantasy plan.

Minnesota held New Orleans to 142 total yards, overcame costly turnovers and improved to 5 and 0 behind Kyler Murray and Aaron Jones.

Drake Maye delivered four passing touchdowns and a rushing score as New England piled up 536 yards and overwhelmed Las Vegas.

Will Anderson Jr. recorded three sacks, Ka'imi Fairbairn supplied four field goals and Houston shut Tennessee out after its opening score.

Jaylen Warren scored on an 80 yard reception and a 50 yard run as Pittsburgh's big plays overwhelmed Indianapolis.

A fourth down stop, two late takeaways and 13 unanswered fourth quarter points carried Denver past Los Angeles.

Jordan Love threw for 367 yards, Christian Watson caught two long touchdowns and Green Bay forced five turnovers against Chicago.

Braelon Allen's 22 yard touchdown run and a relentless Jets pass rush turned a rainy afternoon into a comeback win over Cleveland.