Rams vs 49ers Week 10 Preview: Betting Odds & Predictions
- Football Nation
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Rams vs 49ers Week 10 Preview: Battling for NFC West Supremacy
Sunday, November 9, Levi's Stadium in Santa Clara, California, sets the stage for a crucial NFC West showdown between the Los Angeles Rams and San Francisco 49ers. Both teams are neck and neck for division control, making this clash highly consequential for playoff seeding. The Rams enter as 3.5-point favorites on the road, with kickoff at 4:25 p.m. ET on FOX.
Recent Form and Context
The Rams (6-2) are rolling with three straight dominant wins, including blowouts over the Saints (34-10) and Jaguars (35-7), and a strong defensive showing against the Ravens (17-3). Their defense has allowed only 20 points in these last three games, complementing an effective offense led by quarterback Matthew Stafford. The Rams have covered the spread in 6 of 8 games this season, boasting a 2-1 ATS mark on the road.
The 49ers, also sitting at 6-3, have weathered numerous injuries, especially on defense, yet still maintain one of the toughest home records in the league at 2-1. Their recent win against the Giants (34-24) highlighted Christian McCaffrey’s dual-threat abilities, the heart of San Francisco’s offensive game plan. Despite injuries, the 49ers maintain a competitive edge, going 5-4 against the spread on the year.
Injury Updates and Impact
San Francisco’s defense has been decimated by injuries to Nick Bosa and Fred Warner, both out for the season. Bryce Huff, Mykel Williams, and others also harbor doubts entering Week 10, significantly thinning the 49ers' defensive front. On offense, Brock Purdy remains questionable, with Brandon Aiyuk ruled out, amplifying reliance on Christian McCaffrey.
The Rams also face some uncertainty—with wide receiver Puka Nacua listed as questionable, his availability could influence the passing game’s fluidity. Defensive back Darious Williams is also questionable but likely to play.
Tactical Matchup: Rams Offense vs 49ers Defense
The Rams rank third in offensive DVOA (excluding Week 9), with a potent aerial attack that should challenge the injury-riddled 49ers defense, which ranked 27th in pass defense DVOA entering Week 9. Houston and the Giants both scored 24+ points against San Francisco’s secondary, signaling vulnerability.
The 49ers lean heavily on Christian McCaffrey, who has carried over 180 touches so far, accounting for over a third of the team’s offensive yardage. However, he faces a Rams run defense that allows fewer than 100 yards on the ground per game, forcing San Francisco potentially into risky passing situations.
Players to Watch
Christian McCaffrey (49ers)
McCaffrey remains San Francisco’s offensive cornerstone, racking up over 596 rushing yards and 626 receiving yards with multiple touchdowns. His ability to generate yards both on the ground and through the air presents the 49ers the best chance to breach the Rams’ stout defense.
Kyren Williams (Rams)
Williams has been a reliable complementary back for the Rams in 2025, rushing for 586 yards on 132 carries (4.4-yard average) with three rushing touchdowns and adding 166 yards receiving. He is effective between the tackles and has shown big-play ability with long runs and receptions, making him a vital part of the Rams’ balanced offense, especially in complementing Matthew Stafford’s passing game.
Puka Nacua (Rams)
Nacua, though listed as questionable, is a key receiver for the Rams. When healthy, he stretches defenses with his route running and yard-after-catch ability. His presence would keep the 49ers' secondary honest, opening up opportunities for other skill players. His potential absence could slightly dampen the Rams’ downfield passing threat.
Historical and Betting Trends
This rivalry rarely produces blowouts. The Rams and 49ers games usually stay close—last season's contests were decided by six and three points, respectively. Given the Rams' current form and superior health, the spread favors L.A. covering the 3.5 points on the road.
The total points line is set near 49.5. Historically, three of the last four meetings have hit the Under, and with both teams possessing strong defensive units (especially the Rams) and injury concerns limiting explosive plays, the Under looks a smart play.
Final Predictions and Betting Angles
Spread: Los Angeles Rams -3.5 (-110)The Rams’ recent dominance and healthier roster push the pick toward L.A. covering in a closely contested battle.
Moneyline: Rams -190, 49ers +155The Rams are favorites but the rivalry’s intensity and home advantage make the 49ers enticing on the plus side.
Total Points:Â Under 49.5 (-110)Expect defense and playoff intensity to limit scoring.
Viewing Information
Date & Time:Â Sunday, November 9, 4:25 p.m. ET
Location:Â Levi's Stadium, Santa Clara, CA
Broadcast:Â FOX
This Week 10 showdown between the Rams and 49ers promises playoff implications, rivalry intensity, and strategic chess matches on both sides of the ball. The Rams are poised to keep their winning streak and cover the tight spread thanks to Kyren Williams’ consistent dual-threat running and the threat of Puka Nacua’s receiving prowess when available. Meanwhile, Christian McCaffrey’s efforts will be pivotal for San Francisco’s hopes at home.