NFL Week 13 Injury Report 2025: Updates, Fantasy Impact & Key Outs

We witnessed the fantasy football impact of a late-season injury in Week 12 when the Green Bay Packers were without their leading running back Josh Jacobs due to a knee issue. Emanuel Wilson stepped up and delivered a strong performance with two touchdowns, tallying 25.5 fantasy points in the Packers' victory over the Vikings. With a short week ahead, Jacobs' status will be closely monitored as the Packers prepare to face the Lions on Thanksgiving. Additionally, a comprehensive NFL injury update with fantasy analysis is available for key players.

Joe Burrow (QB, Bengals - toe) nearly returned from injured reserve in Week 12 but was ultimately sidelined. The expectation now is that Burrow will make his comeback on Thanksgiving against the Baltimore Ravens, a critical game for Cincinnati's playoff chances. Burrow's return would bolster all Bengals receivers, although running back Chase Brown’s workload in Burrow’s absence (27 carries in two games) is notable.

Tee Higgins (WR, Bengals) suffered a concussion after a hard fall during a catch attempt in Sunday's loss to New England. He did not return and has been ruled out for the upcoming Thursday night game. Ja'Marr Chase’s return from suspension should result in a surge in targets, while receiver Andrei Iosivas emerges as an intriguing waiver wire option. Tight end Mike Gesicki could be worth monitoring for short-term fantasy value.

Baker Mayfield (QB, Buccaneers) left Sunday Night Football in the second quarter with a sprain to his non-throwing shoulder. With the Bucs trailing significantly, Mayfield avoided further risk. Teddy Bridgewater relieved Mayfield, posting modest numbers. Mayfield was scheduled for an MRI on Monday, with further updates expected regarding his availability for Week 13 against the Cardinals.

Aaron Rodgers (QB, Steelers) is projected to return in Week 13 against the Bills following a Week 12 absence due to a fractured left wrist on his non-throwing hand. His return would provide a marginal boost for receivers DK Metcalf and Calvin Austin III. Steelers’ offensive focus should remain on running backs Jaylen Warren and Kenneth Gainwell, who are currently the top fantasy options on the team.

Josh Jacobs (RB, Packers), sidelined in Week 12 with a knee injury, participated in limited practices previously and the short turnaround for the Thanksgiving game against Detroit may necessitate additional rest. Emanuel Wilson’s capable fill-in performance secures his status as a strong fantasy RB if Jacobs remains out.

Drake London (WR, Falcons) missed Week 12 due to a knee injury, and the Falcons may err on the side of caution, potentially sidelining London for the remainder of the season. This presents a significant loss for both Atlanta’s offense and fantasy managers. Backup quarterback Kirk Cousins performed moderately last Sunday, but the Falcons passing attack offers limited fantasy upside without London.

Alvin Kamara (RB, Saints) exited early in Sunday’s game with a knee injury and did not return. His backup, Devin Neal, took on the majority of the workload, demonstrating some pass-catching ability, which lends him flex appeal should Kamara miss time. The Saints may shift towards a pass-heavy game plan if they are underdogs in Week 13.

Jayden Daniels (QB, Commanders) remains a long shot for Week 13 against the Broncos due to an elbow injury but is expected to resume some practice soon. With Daniels sidelined, Marcus Mariota will start against a challenging defensive opponent.

J.J. McCarthy (QB, Vikings) entered concussion protocol following Week 12 and will likely miss Week 13. Max Brosmer is anticipated to start, offering hope for improved offensive output for Vikings’ receivers Justin Jefferson and Jordan Addison.

Omarion Hampton (RB, Chargers) has been on injured reserve since Week 6 with an ankle injury but recently entered a 21-day practice window, signaling a potential return soon. His reentry into the lineup will likely reduce the role of fill-in back Kimani Vidal.

Week 13 NFL Injury List Highlights

Quarterbacks:

• Joe Burrow, Bengals (Toe)

• Baker Mayfield, Buccaneers (Shoulder)

• Aaron Rodgers, Steelers (Wrist)

• Dillon Gabriel, Browns (Concussion)

• Jayden Daniels, Commanders (Elbow)

• J.J. McCarthy, Vikings (Concussion)

Running Backs:

• Josh Jacobs, Packers (Knee)

• Bucky Irving, Buccaneers (Shoulder/Foot)

• Alvin Kamara, Saints (Knee)

• Trey Benson, Cardinals (Knee; IR)

• Isiah Pacheco, Chiefs (Knee, will play)

• Omarion Hampton, Chargers (Ankle)

Wide Receivers:

• Tee Higgins, Bengals (Concussion - Out)

• Drake London, Falcons (Knee)

• Brian Thomas Jr., Jaguars (Ankle)

• Marvin Harrison Jr., Cardinals (Appendix)

• Chris Godwin Jr., Buccaneers (Leg)

• Terry McLaurin, Commanders (Quad)

• Matthew Golden, Packers (Shoulder)

• Others with various injuries

Tight Ends:

• Dalton Kincaid, Bills (Hamstring)

• Darren Waller, Dolphins (Pectoral)

• Michael Mayer, Raiders (Ankle)

Players Out for the Season

Key players confirmed out include Malik Nabers (Giants), Tyreek Hill (Dolphins), Najee Harris (Chargers), Austin Ekeler (Commanders), Antonio Gibson (Patriots), Miles Sanders (Cowboys), Cam Skattebo (Giants), and others with season-ending injuries predominantly involving knees, Achilles, or major fractures.